"Upon the March We Fittest Die" is the thirteenth episode season three of the science fiction television series Defiance and the thirty-ninth and final episode of the series overall. It was directed by Michael Nankin with a script written by series creator Kevin Murphy. The episode first aired on Syfy on Friday, August 28th, 2015 at 9:00 pm. In this episode, Joshua Nolan, Irisa Nyira and Doc Yewll embark upon a dangerous mission to the Tsuroz to blow up the ship before the insane Kindzi can unleash hundreds of murderous Omec upon the world. Complicating matters even further is the fact for some of them, this may be a one-way trip. Irisa makes a startling discovery that alters their plans.
This episode had a viewership of 1.165 million people; .22% in the 18-49 age demographic. This is up by .034 from the previous episode. 
This is the first and only appearance of Nueve. She is the only character seen in this episode (discounting background extras) who has not appeared in a previous episode.
On October 16th, 2015, Syfy announced that it would not be renewing Defiance for a fourth season. The program's cancellation came just days after Syfy announced the discontinuation of another series, Dominion. 
Final episode of the series. Final appearance of all characters.
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