Franchise creator Wes Craven passed away in Los Angeles, California on Sunday, August 30th, 2015 at the age of 76 after having battled brain cancer for some time. He had been working in L.A. at the time of his death, but still divided his time between there and his home in Martha's Vineyard. 
A special "In memory of..." tribute to Wes Craven was presented before the airing of the season finale, "Revelations".
Nina Patterson is the first character to appear in Scream: The Series, and as such, she is also the first female character. She is the second character killed on the show, after Tyler O'Neill, but is the first on-screen death. She is the first female character on the series to die.
The identity of the primary Ghostface killer from season one is revealed at the end of the season finale, "Revelations".